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KMID : 0043320170400020250
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Archives of Pharmacal Research
2017 Volume.40 No. 2 p.250 ~ p.257
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Moisturizing effect of serine-loaded solid lipid nanoparticles and polysaccharide-rich extract of root Phragmites communis incorporated in hydrogel bases
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Barua Sonia
Kim Hyeong-Min
Hong Seong-Chul
Yoo Seung-Yup
Shin Do-Hyun
Lee Chung-Lyol
Na Seon-Jeong
Kim Yeong-Hyo
Jo Kang-Hee
Yun Gyi-Ae
Kim Joong-Hark
Sohn Uy-Dong
Lee Jae-Hwi
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Abstract
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This study evaluated the moisturizing effect of serine-loaded solid lipid nanoparticles (serine-SLN) and polysaccharide-rich reed (Phragmites communis) root extract (RRE) incorporated in hydrogel bases. The hydrogels with serine-SLN and/or RRE were carefully applied on the volar forearm of human volunteers. Their moisturizing efficacy was evaluated by monitoring conductance values using a skin surface hygrometer. The values of the area under the normalized conductance-time curve (AUCC) were developed and compared as a parameter for the water holding capacity of the skin. Hydrogels with serine-SLN did not significantly moisturize the skin, while hydrogel containing 0.25% RRE produced a significant increase in the moisture content of the skin. However, adding more than 0.25% of RRE into the hydrogel base decreased the moisturizing effect due to the marked reduction of viscosity. Significantly enhanced moisturizing effect was observed with the hydrogel containing 0.25% RRE and 3% serine-SLN, with AUCC increased 2.21 times compared to than blank hydrogel. The results imply that effective delivery of serine into the skin is possible using lipid-based nanocarriers and RRE, which could be a promising strategy to moisturize the skin effectively.
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KEYWORD
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Phragmites rhizoma, Reed root extract Serine, Solid lipid nanoparticles, Skin moisturization
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